Molecular and Integrative Toxicology Essential and Non-Essential Metals: Carcinogenesis Prevention and Cancer Therapeutics (Hardcover)

This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals about two scores of them the authors will instead provide a detailed analysis of a select set of essential (Calcium Magnesium Selenium Iron copper and Zinc) and non-essential metals (Nickel Chromium Cadmium and Arsenic Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play their carcinogenic and cancer therapeutics by integrating epidemiological experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS kinase families receptors endoplasmic mitochondrial players and epigenetics. As part of integrating the human experimental and mechanistic data as well as a detailed analysis into the modes of actionfor different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.